Exacerbated Renal and Hematologic Toxicities to Ifosfamide and Doxorubicin-Based Chemotherapy in a Patient with Retroperitoneal Liposarcoma Harboring a Germline Mutation in the WRN Gene

Exacerbated Renal and Hematologic Toxicities to Ifosfamide and Doxorubicin-Based Chemotherapy in a Patient with Retroperitoneal Liposarcoma Harboring a Germline Mutation in the WRN Gene

Werner’s syndrome is caused by the inactivation of both WRN alleles and is characterized by premature aging and increased risk of neoplasms, especially those of mesenchymal origins, such as sarcomas. Given the characteristic genomic instability, patients with this syndrome are more susceptible to de...

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Bibliographic Details
Main Authors: Beatriz Mendes Awni, Carlos Diego Holanda Lopes, Guilherme Harada, Alessandra Corte Real Salgues, Gilmar de Andrade França, Leonardo de Abreu Testagrossa, Marcelo Araujo Queiroz, Adriano Gonçalves e Silva, Fabio de Oliveira Ferreira, Rodrigo Ramella Munhoz
Format: Article
Language:English
Published: Karger Publishers 2022-03-01
Series:Case Reports in Oncology
Subjects:
werner’s syndrome
wrn
liposarcoma
hematological and renal toxicities
Online Access:https://www.karger.com/Article/FullText/521624

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https://www.karger.com/Article/FullText/521624

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