SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.

SERINC5 is a host restriction factor that impairs infectivity of HIV-1 and other primate lentiviruses and is counteracted by the viral accessory protein Nef. However, the importance of SERINC5 antagonism for viral replication and cytopathicity remained unclear. Here, we show that the Nef protein of...

詳細記述

書誌詳細
主要な著者: Dorota Kmiec, Bengisu Akbil, Swetha Ananth, Dominik Hotter, Konstantin M J Sparrer, Christina M Stürzel, Birthe Trautz, Ahidjo Ayouba, Martine Peeters, Zhong Yao, Igor Stagljar, Vânia Passos, Thomas Zillinger, Christine Goffinet, Daniel Sauter, Oliver T Fackler, Frank Kirchhoff
フォーマット: 論文
言語:English
出版事項: Public Library of Science (PLoS) 2018-08-01
シリーズ:PLoS Pathogens
オンライン･アクセス:http://europepmc.org/articles/PMC6117100?pdf=render

インターネット

http://europepmc.org/articles/PMC6117100?pdf=render

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