Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds

Nucleic acids are useful for biomedical targeting and sensing applications in which the molecular environment is different from that of a dilute aqueous solution. In this study, the influence of various types of mixed solutions of water and water-soluble organic compounds on RNA was investigated by...

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Bibliographic Details
Main Authors: Shu-ichi Nakano, Yuichi Kitagawa, Daisuke Miyoshi, Naoki Sugimoto
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000643