Calcineurin-independent NFATc1 signaling is essential for survival of Burkitt lymphoma cells

Calcineurin-independent NFATc1 signaling is essential for survival of Burkitt lymphoma cells

In Burkitt lymphoma (BL), a tumor of germinal center B cells, the pro-apoptotic properties of MYC are controlled by tonic B cell receptor (BCR) signals. Since BL cells do not exhibit constitutive NF-κB activity, we hypothesized that anti-apoptotic NFATc1 proteins provide a major transcriptional surv...

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Bibliographic Details
Main Authors: Krisna Murti, Hendrik Fender, Carolin Glatzle, Rhoda Wismer, Salvador Sampere-Birlanga, Vanessa Wild, Khalid Muhammad, Andreas Rosenwald, Edgar Serfling, Andris Avots
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
apoptosis
Burkitt lymphoma
cyclosporin A
nuclear localization
NFATc1
activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1205788/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1205788/full

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