Identification of the protein coding capability of coronavirus defective viral genomes by mass spectrometry

Identification of the protein coding capability of coronavirus defective viral genomes by mass spectrometry

Abstract During coronavirus infection, in addition to the well-known coronavirus genomes and subgenomic mRNAs, an abundance of defective viral genomes (DVGs) can also be synthesized. In this study, we aimed to examine whether DVGs can encode proteins in infected cells. Nanopore direct RNA sequencing...

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Bibliographic Details
Main Authors: Ching-Hung Lin, Feng-Cheng Hsieh, Chien-Chen Lai, Wei-Chen Wang, Cheng-Yu Kuo, Chun-Chun Yang, Hsuan-Wei Hsu, Hon-Man-Herman Tam, Cheng-Yao Yang, Hung-Yi Wu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Virology Journal
Subjects:
Coronavirus
Defective viral genome
Protein coding
Gene expression
Pathogenesis
Online Access:https://doi.org/10.1186/s12985-023-02252-3

Internet

https://doi.org/10.1186/s12985-023-02252-3

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