Ophiobolin O Isolated from Aspergillus ustus Induces G1 Arrest of MCF-7 Cells through Interaction with AKT/GSK3β/Cyclin D1 Signaling

Ophiobolin O Isolated from Aspergillus ustus Induces G1 Arrest of MCF-7 Cells through Interaction with AKT/GSK3β/Cyclin D1 Signaling

Ophiobolin O is a member of ophiobolin family, which has been proved to be a potent anti-tumor drug candidate for human breast cancer. However, the anti-tumor effect and the mechanism of ophiobolin O remain unclear. In this study, we further verified ophiobolin O-induced G1 phase arrest in human bre...

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Bibliographic Details
Main Authors: Cuiting Lv, Wenxing Qin, Tonghan Zhu, Shanjian Wei, Kui Hong, Weiming Zhu, Ruohua Chen, Caiguo Huang
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Marine Drugs
Subjects:
ophiobolin O
G1 arrest
AKT/GSK3β/cyclin D1 signaling
Online Access:http://www.mdpi.com/1660-3397/13/1/431

Internet

http://www.mdpi.com/1660-3397/13/1/431

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