A high-throughput screening assay for mutant isocitrate dehydrogenase 1 using acoustic droplet ejection mass spectrometry

A high-throughput screening assay for mutant isocitrate dehydrogenase 1 using acoustic droplet ejection mass spectrometry

Acoustic droplet ejection mass spectrometry (ADE-MS) has recently emerged as a promising label-free, MS-based readout method for high throughput screening (HTS) campaigns in early pharmaceutical drug discovery, since it enables high-speed analysis directly from 384- or 1536-well plates. In this manu...

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Bibliographic Details
Main Authors: Elisabeth Speckmeier, Antje Pommereau, Kay-Christoph Grosser, Hartmut Mors, Thomas C. Maier, Thomas Licher, Felix Bärenz
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:SLAS Discovery
Subjects:
Isocitrate dehydrogenase type 1 (IDH1)
IDH1 R132H inhibitors
Acoustic droplet ejection mass spectrometry (ADE-MS)
Echo-MS
Open port interface
Label-free high throughput screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555222136610

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http://www.sciencedirect.com/science/article/pii/S2472555222136610

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