Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States.
Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder characterized by progressive degeneration of upper motor neurons and lower motor neurons, and frontotemporal regions resulting in impaired bulbar, limb, and cognitive function. Magnetic resonance imaging studies have rep...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0269154 |
| _version_ | 1818193471517753344 |
|---|---|
| author | Komal Bharti Simon J Graham Michael Benatar Hannah Briemberg Sneha Chenji Nicolas Dupré Annie Dionne Richard Frayne Angela Genge Lawrence Korngut Collin Luk Lorne Zinman Sanjay Kalra Canadian ALS Neuroimaging Consortium (CALSNIC) |
| author_facet | Komal Bharti Simon J Graham Michael Benatar Hannah Briemberg Sneha Chenji Nicolas Dupré Annie Dionne Richard Frayne Angela Genge Lawrence Korngut Collin Luk Lorne Zinman Sanjay Kalra Canadian ALS Neuroimaging Consortium (CALSNIC) |
| author_sort | Komal Bharti |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder characterized by progressive degeneration of upper motor neurons and lower motor neurons, and frontotemporal regions resulting in impaired bulbar, limb, and cognitive function. Magnetic resonance imaging studies have reported cortical and subcortical brain involvement in the pathophysiology of ALS. The present study investigates the functional integrity of resting-state networks (RSNs) and their importance in ALS. Intra- and inter-network resting-state functional connectivity (Rs-FC) was examined using an independent component analysis approach in a large multi-center cohort. A total of 235 subjects (120 ALS patients; 115 healthy controls (HC) were recruited across North America through the Canadian ALS Neuroimaging Consortium (CALSNIC). Intra-network and inter-network Rs-FC was evaluated by the FSL-MELODIC and FSLNets software packages. As compared to HC, ALS patients displayed higher intra-network Rs-FC in the sensorimotor, default mode, right and left fronto-parietal, and orbitofrontal RSNs, and in previously undescribed networks including auditory, dorsal attention, basal ganglia, medial temporal, ventral streams, and cerebellum which negatively correlated with disease severity. Furthermore, ALS patients displayed higher inter-network Rs-FC between the orbitofrontal and basal ganglia RSNs which negatively correlated with cognitive impairment. In summary, in ALS there is an increase in intra- and inter-network functional connectivity of RSNs underpinning both motor and cognitive impairment. Moreover, the large multi-center CALSNIC dataset permitted the exploration of RSNs in unprecedented detail, revealing previously undescribed network involvement in ALS. |
| first_indexed | 2024-12-12T00:46:56Z |
| format | Article |
| id | doaj.art-3d7e9e5f78ad40c8b6a3be9ee90013bf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T00:46:56Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3d7e9e5f78ad40c8b6a3be9ee90013bf2022-12-22T00:44:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01176e026915410.1371/journal.pone.0269154Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States.Komal BhartiSimon J GrahamMichael BenatarHannah BriembergSneha ChenjiNicolas DupréAnnie DionneRichard FrayneAngela GengeLawrence KorngutCollin LukLorne ZinmanSanjay KalraCanadian ALS Neuroimaging Consortium (CALSNIC)Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder characterized by progressive degeneration of upper motor neurons and lower motor neurons, and frontotemporal regions resulting in impaired bulbar, limb, and cognitive function. Magnetic resonance imaging studies have reported cortical and subcortical brain involvement in the pathophysiology of ALS. The present study investigates the functional integrity of resting-state networks (RSNs) and their importance in ALS. Intra- and inter-network resting-state functional connectivity (Rs-FC) was examined using an independent component analysis approach in a large multi-center cohort. A total of 235 subjects (120 ALS patients; 115 healthy controls (HC) were recruited across North America through the Canadian ALS Neuroimaging Consortium (CALSNIC). Intra-network and inter-network Rs-FC was evaluated by the FSL-MELODIC and FSLNets software packages. As compared to HC, ALS patients displayed higher intra-network Rs-FC in the sensorimotor, default mode, right and left fronto-parietal, and orbitofrontal RSNs, and in previously undescribed networks including auditory, dorsal attention, basal ganglia, medial temporal, ventral streams, and cerebellum which negatively correlated with disease severity. Furthermore, ALS patients displayed higher inter-network Rs-FC between the orbitofrontal and basal ganglia RSNs which negatively correlated with cognitive impairment. In summary, in ALS there is an increase in intra- and inter-network functional connectivity of RSNs underpinning both motor and cognitive impairment. Moreover, the large multi-center CALSNIC dataset permitted the exploration of RSNs in unprecedented detail, revealing previously undescribed network involvement in ALS.https://doi.org/10.1371/journal.pone.0269154 |
| spellingShingle | Komal Bharti Simon J Graham Michael Benatar Hannah Briemberg Sneha Chenji Nicolas Dupré Annie Dionne Richard Frayne Angela Genge Lawrence Korngut Collin Luk Lorne Zinman Sanjay Kalra Canadian ALS Neuroimaging Consortium (CALSNIC) Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States. PLoS ONE |
| title | Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States. |
| title_full | Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States. |
| title_fullStr | Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States. |
| title_full_unstemmed | Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States. |
| title_short | Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States. |
| title_sort | functional alterations in large scale resting state networks of amyotrophic lateral sclerosis a multi site study across canada and the united states |
| url | https://doi.org/10.1371/journal.pone.0269154 |
| work_keys_str_mv | AT komalbharti functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT simonjgraham functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT michaelbenatar functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT hannahbriemberg functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT snehachenji functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT nicolasdupre functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT anniedionne functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT richardfrayne functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT angelagenge functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT lawrencekorngut functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT collinluk functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT lornezinman functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT sanjaykalra functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates AT canadianalsneuroimagingconsortiumcalsnic functionalalterationsinlargescalerestingstatenetworksofamyotrophiclateralsclerosisamultisitestudyacrosscanadaandtheunitedstates |