Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells

Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells

Oncolytic herpes simplex viruses (oHSV) are under development for the treatment of a variety of human cancers, including breast cancer, a leading cause of cancer mortality among women worldwide. Here we report the design of a fully retargeted oHSV for preferential infection of breast cancer cells th...

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Bibliographic Details
Main Authors: Bonnie L. Hall, Daniela Leronni, Yoshitaka Miyagawa, William F. Goins, Joseph C. Glorioso, Justus B. Cohen
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
oncolytic
herpes simplex virus
breast cancer
Online Access:https://www.mdpi.com/1422-0067/21/22/8815

Internet

https://www.mdpi.com/1422-0067/21/22/8815

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