Novel potential pharmacological applications of dimethyl fumarate—an overview and update

Novel potential pharmacological applications of dimethyl fumarate—an overview and update

Dimethyl fumarate (DMF) is an FDA-approved drug for the treatment of psoriasis and multiple sclerosis. DMF is known to stabilize the transcription factor Nrf2, which in turn induces the expression of antioxidant response element genes. It has also been shown that DMF influences autophagy and partici...

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Bibliographic Details
Main Authors: Giorgia Bresciani, Federico Manai, Sergio Davinelli, Paolo Tucci, Luciano Saso, Marialaura Amadio
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
Nrf2 pathway
drug repurposing
dimethyl fumarate
inflammation
oxidative stress
antioxidant
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1264842/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1264842/full

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