HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity

HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity

Defective erythropoiesis is one of the causes of anemia and leukemia. However, the mechanisms underlying defective erythropoiesis under a low-dose environment of benzene are poorly understood. In the present study, multiple omics (transcriptomics and metabolomics) and methods from epidemiology to ex...

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Bibliographic Details
Main Authors: Xiaowei Cong, Xiaoqin Li, Kai Xu, Lihong Yin, Geyu Liang, Rongli Sun, Yuepu Pu, Juan Zhang
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Environment International
Subjects:
Low-dose benzene
Stem cells
Iron homeostasis
Epigenetic modification
Macrophage-related immunosurveillance
Erythropoiesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412024000795

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http://www.sciencedirect.com/science/article/pii/S0160412024000795

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