Targeting MicroRNA-125b Promotes Neurite Outgrowth but Represses Cell Apoptosis and Inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-Dependent Way in Alzheimer Disease

Targeting MicroRNA-125b Promotes Neurite Outgrowth but Represses Cell Apoptosis and Inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-Dependent Way in Alzheimer Disease

This study aimed to explore the molecular regulatory network among microRNA-125b (miR-125b), forkhead box Q1 (FOXQ1), prostaglandin-endoperoxide synthase 2 (PTGS2), and cyclin-dependent kinase 5 (CDK5), as well as their effects on cell apoptosis, neurite outgrowth, and inflammation in Alzheimer dise...

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Bibliographic Details
Main Authors: Jingcong Zhuang, Zhongjie Chen, Pingping Cai, Rong Wang, Qingwei Yang, Longling Li, Huili Yang, Renjing Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
MicroRNA-125b
Alzheimer's disease
FOXQ1
PTGS2
CDK5
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.587747/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.587747/full

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