Extracellular Release of Citrullinated Vimentin Directly Acts on Osteoclasts to Promote Bone Resorption in a Mouse Model of Periodontitis

Extracellular Release of Citrullinated Vimentin Directly Acts on Osteoclasts to Promote Bone Resorption in a Mouse Model of Periodontitis

Elevated osteoclast (OC)-mediated bone resorption, a common pathological feature between periodontitis and rheumatoid arthritis (RA), implicates a possible mutually shared pathogenesis. The autoantibody to citrullinated vimentin (CV), a representative biomarker of RA, is reported to promote osteocla...

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Bibliographic Details
Main Authors: Satoru Shindo, Roodelyne Pierrelus, Atsushi Ikeda, Shin Nakamura, Alireza Heidari, Maria Rita Pastore, Elizabeth Leon, Sunniva Ruiz, Harsh Chheda, Rhea Khatiwala, Tomoki Kumagai, George Tolson, Islam Elderbashy, Kazuhisa Ouhara, Xiaozhe Han, Maria Hernandez, Saynur Vardar-Sengul, Hideki Shiba, Toshihisa Kawai
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
citrullinated vimentin
osteoclast
periodontitis
Cl-amidine
PKC-δ
peptidyl arginine deiminase
Online Access:https://www.mdpi.com/2073-4409/12/8/1109

Internet

https://www.mdpi.com/2073-4409/12/8/1109

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