Structural changes in the collagen network of joint tissues in late stages of murine OA

Abstract Osteoarthritis (OA) is the most prevalent degenerative joint disease, resulting in joint pain, impaired movement, and structural changes. As the ability of joint tissue to resist stress is mainly imparted by fibrillar collagens in the extracellular matrix, changes in the composition and str...

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Bibliographic Details
Main Authors: Natalie K. Yoshioka, Gregory M. Young, Deepak Kumar Khajuria, Vengadeshprabhu Karuppagounder, William J. Pinamont, Julie C. Fanburg-Smith, Thomas Abraham, Reyad A. Elbarbary, Fadia Kamal
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-13062-y