Insulin Therapy is Associated With Increased Myocardial Interstitial Fibrosis and Cardiomyocyte Apoptosis in a Rodent Model of Experimental Diabetes

Insulin Therapy is Associated With Increased Myocardial Interstitial Fibrosis and Cardiomyocyte Apoptosis in a Rodent Model of Experimental Diabetes

The incidence of diabetes mellitus (DM) is rising. DM is a risk factor for developing left ventricular (LV) dysfunction and adverse cardiovascular outcomes. Insulin, commonly used to treat DM, is associated with further worsening of such outcomes. Yet, the pathophysiology of the adverse properties o...

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Bibliographic Details
Main Authors: Fadi W. Adel, Ye Zheng, Siu-Hin Wan, Christie Greason, Shuchong Pan, Syed Ameenuddin, Horng H. Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Physiology
Subjects:
insulin
diabetes
fibrosis
apoptosis
rat model
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.890907/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.890907/full

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