Generation of an artificial human B cell line test system using Transpo-mAbTM technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins.

Generation of an artificial human B cell line test system using Transpo-mAbTM technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins.

The antigen-specific targeting of autoreactive B cells via their unique B cell receptors (BCRs) is a novel and promising alternative to the systemic suppression of humoral immunity. We generated and characterized cytolytic fusion proteins based on an existing immunotoxin comprising tetanus toxoid fr...

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Bibliographic Details
Main Authors: Diana Klose, Mira Woitok, Judith Niesen, Roger R Beerli, Ulf Grawunder, Rainer Fischer, Stefan Barth, Rolf Fendel, Thomas Nachreiner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5509223?pdf=render

Internet

http://europepmc.org/articles/PMC5509223?pdf=render

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