On the roles of intrinsically disordered proteins and regions in cell communication and signaling

Abstract For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured proteins, intrinsically disordered proteins and regions (IDPs and IDRs) also carry ou...

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Bibliographic Details
Main Authors: Sarah E. Bondos, A. Keith Dunker, Vladimir N. Uversky
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Cell Communication and Signaling
Subjects:
Online Access:https://doi.org/10.1186/s12964-021-00774-3