Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report

Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report

Abstract This is the first autopsy report of hepatotoxicity from nivolumab immunotherapy for malignant mesothelioma. The increase in levels of biliary enzymes and randomly distributed endothelial damage were steroid‐refractory, but second‐line option was abandoned because of cachexia. Further discus...

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Bibliographic Details
Main Authors: Kazumori Arai, Masanori Matsuda, Hiromasa Nakayasu, Shiori Meguro, Takafumi Kurokami, Aki Kubota, Tomohiro Iwasaki, Makoto Suzuki, Shinya Kawaguchi, Toshihide Iwashita
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Clinical Case Reports
Subjects:
autopsy
endothelialitis
immune checkpoint inhibitors
immune‐related adverse events
liver
necrosis
Online Access:https://doi.org/10.1002/ccr3.5174

Internet

https://doi.org/10.1002/ccr3.5174

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