Design and Validation of a Multi-Point Injection Technology for MR-Guided Convection Enhanced Delivery in the Brain

Convection enhanced delivery (CED) allows direct intracranial administration of neuro-therapeutics. Success of CED relies on specific targeting and broad volume distributions (VD). However, to prevent off-target delivery and tissue damage, CED is typically conducted with small cannulas and at low fl...

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Bibliographic Details
Main Authors: Kayla Prezelski, Megan Keiser, Joel M. Stein, Timothy H. Lucas, Beverly Davidson, Pedro Gonzalez-Alegre, Flavia Vitale
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Medical Technology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmedt.2021.725844/full