A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies

A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies

Abstract Microglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of research have revealed the dynamic nature of microglial-neuronal interactions, but seldom consider how this dynamism varies with microglial sex differences, leaving a signi...

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Bibliographic Details
Main Authors: Ogochukwu J. Uweru, Akhabue K. Okojie, Aparna Trivedi, Jordan Benderoth, Lauren S. Thomas, Georgia Davidson, Kendall Cox, Ukpong B. Eyo
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
P2RY12
Sex differences
Locomotion
Behavior
Online Access:https://doi.org/10.1186/s12974-024-03079-7

Internet

https://doi.org/10.1186/s12974-024-03079-7

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