Significant improvement of bone marrow-derived MSC expansion from MDS patients by defined xeno-free medium

Significant improvement of bone marrow-derived MSC expansion from MDS patients by defined xeno-free medium

Abstract Background Robust and reliable in vitro and in vivo models of primary cells are necessary to study the pathomechanisms of Myelodysplastic Neoplasms (MDS) and identify novel therapeutic strategies. MDS-derived hematopoietic stem and progenitor cells (HSPCs) are reliant on the support of bone...

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Bibliographic Details
Main Authors: Eva Altrock, Carla Sens-Albert, Franziska Hofmann, Vladimir Riabov, Nanni Schmitt, Qingyu Xu, Johann-Christoph Jann, Felicitas Rapp, Laurenz Steiner, Alexander Streuer, Verena Nowak, Julia Obländer, Nadine Weimer, Iris Palme, Melda Göl, Ali Darwich, Patrick Wuchter, Georgia Metzgeroth, Mohamad Jawhar, Wolf-Karsten Hofmann, Daniel Nowak
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Stem Cell Research & Therapy
Subjects:
Bone marrow-derived mesenchymal stromal cells
Myelodysplastic Neoplasms
Xeno-free expansion
Online Access:https://doi.org/10.1186/s13287-023-03386-5

Internet

https://doi.org/10.1186/s13287-023-03386-5

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