Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer’s disease

Since the discovery of prion diseases, the concept that a transmissible pathogen could be a protein has emerged. As such, this transmissible protein agent can transfer its pathological mis-folded shape to the same but normally folded protein thus leading to the propagation of a disease. This idea is...

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Bibliographic Details
Main Authors: Valerie eVingtdeux, Nicolas eSergeant, Luc eBuee
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00229/full