Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response

Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response

Background CD47 is an integral membrane protein that alters adaptive immunosurveillance when bound to the matricellular glycoprotein thrombospondin-1 (TSP1). We examined the impact of the CD47/TSP1 signaling axis on melanoma patient response to anti-PD-1 therapy due to alterations in T cell activati...

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Bibliographic Details
Main Authors: Wei Zhang, Masaki Terabe, Lance D Miller, Mitra Kooshki, Pierre L Triozzi, Elizabeth R Stirling, Adam S Wilson, Liliya M Yamaleyeva, Martha A Alexander-Miller, David R Soto-Pantoja
Format: Article
Language:English
Published: BMJ Publishing Group 2022-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/11/e004712.full

Internet

https://jitc.bmj.com/content/10/11/e004712.full

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