Minocycline-induced disruption of the intestinal FXR/FGF15 axis impairs osteogenesis in mice

Minocycline-induced disruption of the intestinal FXR/FGF15 axis impairs osteogenesis in mice

Antibiotic-induced shifts in the indigenous gut microbiota influence normal skeletal maturation. Current theory implies that gut microbiota actions on bone occur through a direct gut/bone signaling axis. However, our prior work supports that a gut/liver signaling axis contributes to gut microbiota e...

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Bibliographic Details
Main Authors: Matthew D. Carson, Amy J. Warner, Jessica D. Hathaway-Schrader, Vincenza L. Geiser, Joseph Kim, Joy E. Gerasco, William D. Hill, John J. Lemasters, Alexander V. Alekseyenko, Yongren Wu, Hai Yao, J. Ignacio Aguirre, Caroline Westwater, Chad M. Novince
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-01-01
Series:JCI Insight
Subjects:
Bone biology
Endocrinology
Online Access:https://doi.org/10.1172/jci.insight.160578

Internet

https://doi.org/10.1172/jci.insight.160578

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