TCR mimic compounds for pHLA targeting with high potency modalities in oncology

TCR mimic compounds for pHLA targeting with high potency modalities in oncology

pHLA complexes represent the largest class of cell surface markers on cancer cells, making them attractive for targeted cancer therapies. Adoptive cell therapies expressing TCRs that recognize tumor specific pHLAs take advantage of the unique selectivity and avidity of TCR: pHLA interactions. More r...

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Bibliographic Details
Main Authors: Hans-Peter Gerber, Leonard G. Presta
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
TCR mimic compounds
high potency modalities
protein binder scaffolds
targeted cancer therapy
cancer testis antigen
Antibody Drug Conjugates
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1027548/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1027548/full

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