Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice

Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance between excitation and inhibition, closely linked to the loss/gain of astrocytic func...

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Bibliographic Details
Main Authors: Sara Costa-Pinto, Joana Gonçalves-Ribeiro, Joana Tedim-Moreira, Renato Socodato, João B. Relvas, Ana M. Sebastião, Sandra H. Vaz
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Neurobiology of Disease
Subjects:
ALS
Astrocytes
Primary motor cortex
Synaptic plasticity
Synaptic transmission
Upper synapses
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124000342

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http://www.sciencedirect.com/science/article/pii/S0969996124000342

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