Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway

Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway

Ursodeoxycholic acid (UDCA) is a first-line clinical drug for the treatment of liver diseases. U12, a derivative of UDCA, showed effective anti-hepatoma activities in previous works. However, the low polarity and large doses limited the druglikeness of U12. In this study, the structural modification...

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Bibliographic Details
Main Authors: Renjing Yang, Chunchun Du, Ting Cao, Guanghui Wang, Xin Jiang, Jun Gao, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian, Haifeng Chen
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceuticals
Subjects:
U12 derivatives
U12a
anti-hepatoma activity
Online Access:https://www.mdpi.com/1424-8247/15/1/107

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https://www.mdpi.com/1424-8247/15/1/107

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