A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

ABSTRACT Filoviruses are the causative agents of an increasing number of disease outbreaks in human populations, including the current unprecedented Ebola virus disease (EVD) outbreak in western Africa. One obstacle to controlling these epidemics is our poor understanding of the host range of filovi...

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Bibliographic Details
Main Authors: Esther Ndungo, Andrew S. Herbert, Matthijs Raaben, Gregor Obernosterer, Rohan Biswas, Emily Happy Miller, Ariel S. Wirchnianski, Jan E. Carette, Thijn R. Brummelkamp, Sean P. Whelan, John M. Dye, Kartik Chandran
Format: Article
Language:English
Published: American Society for Microbiology 2016-04-01
Series:mSphere
Subjects:
Ebola virus
NPC1
Niemann-Pick C1
endosomal receptor
filovirus
intracellular receptor
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00007-16

Internet

https://journals.asm.org/doi/10.1128/mSphere.00007-16

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