Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier

Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier

Abstract Background The multidrug resistance (MDR) transporters, P-glycoprotein (P-gp, encoded by ABCB1) and breast cancer resistance protein (BCRP/ABCG2) contribute to the blood–brain barrier (BBB), protecting the brain from drug exposure. The impact of infection on MDR in the developing human BBB...

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Bibliographic Details
Main Authors: Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier (BBB)
Toll like receptor (TLR)
Lipopolysaccharide (LPS)
Polyinosinic polycytidylic acid (Poly I:C)
Single-stranded RNA (ssRNA)
Multidrug resistance (MDR) transporters
Online Access:https://doi.org/10.1186/s12987-023-00409-4

Internet

https://doi.org/10.1186/s12987-023-00409-4

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