Gut bacteria interact directly with colonic mast cells in a humanized mouse model of IBS

Both mast cells and microbiota play important roles in the pathogenesis of Irritable Bowel Syndrome (IBS), however the precise mechanisms are unknown. Using microbiota-humanized IBS mouse model, we show that colonic mast cells and mast cells co-localized with neurons were higher in mice colonized wi...

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Bibliographic Details
Main Authors: Chiko Shimbori, Giada De Palma, Lauren Baerg, Jun Lu, Elena F. Verdu, David E. Reed, Stephen Vanner, Stephen M. Collins, Premysl Bercik
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2105095