Gut bacteria interact directly with colonic mast cells in a humanized mouse model of IBS
Both mast cells and microbiota play important roles in the pathogenesis of Irritable Bowel Syndrome (IBS), however the precise mechanisms are unknown. Using microbiota-humanized IBS mouse model, we show that colonic mast cells and mast cells co-localized with neurons were higher in mice colonized wi...
Main Authors: | Chiko Shimbori, Giada De Palma, Lauren Baerg, Jun Lu, Elena F. Verdu, David E. Reed, Stephen Vanner, Stephen M. Collins, Premysl Bercik |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2022-12-01
|
Series: | Gut Microbes |
Subjects: | |
Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2105095 |
Similar Items
-
Mast Cell Regulation and Irritable Bowel Syndrome: Effects of Food Components with Potential Nutraceutical Use
by: José Antonio Uranga, et al.
Published: (2020-09-01) -
Role of the nuclear receptor subfamily 4a in mast cells in the development of irritable bowel syndrome
by: Ruidi Li, et al.
Published: (2022-01-01) -
The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets
by: Elden Berla Thangam, et al.
Published: (2018-08-01) -
Apigenin attenuates visceral hypersensitivity in water avoidance stress rats by modulating the microbiota-gut-brain axis and inhibiting mast cell activation
by: Yuan Xia, et al.
Published: (2023-11-01) -
Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation
by: Maria Pilar Blasco, et al.
Published: (2020-05-01)