Neuronal Sprouting and Reorganization in Bone Tissue Infiltrated by Human Breast Cancer Cells

Neuronal Sprouting and Reorganization in Bone Tissue Infiltrated by Human Breast Cancer Cells

BackgroundPain is a common complication for patients with metastatic bone disease. Animal models suggest that the pain, in part, is driven by pathological sprouting and reorganization of the nerve fibers innervating the bone. Here, we investigate how these findings translate to humans.MethodsBone bi...

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Bibliographic Details
Main Authors: Rie B. Hansen, Manasi Sayilekshmy, Michala S. Sørensen, Astrid H. Jørgensen, Ida B. Kanneworff, Emma K. E. Bengtsson, Tomas A. Grum-Schwensen, Michael M. Petersen, Charlotte Ejersted, Thomas L. Andersen, Christina M. Andreasen, Anne-Marie Heegaard
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pain Research
Subjects:
cancer-induced bone pain
metastatic bone disease
neuronal sprouting
bone
innervation
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2022.887747/full

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https://www.frontiersin.org/articles/10.3389/fpain.2022.887747/full

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