Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome

Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome

Summary: MECP2 loss-of-function mutations cause Rett syndrome, a neurodevelopmental disorder resulting from a disrupted brain transcriptome. How these transcriptional defects are decoded into a disease proteome remains unknown. We studied the proteome of Rett cerebrospinal fluid (CSF) to identify co...

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Bibliographic Details
Main Authors: Stephanie A. Zlatic, Duc Duong, Kamal K.E. Gadalla, Brenda Murage, Lingyan Ping, Ruth Shah, James J. Fink, Omar Khwaja, Lindsay C. Swanson, Mustafa Sahin, Sruti Rayaprolu, Prateek Kumar, Srikant Rangaraju, Adrian Bird, Daniel Tarquinio, Randall Carpenter, Stuart Cobb, Victor Faundez
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Disease
Pathophysiology
Clinical neuroscience
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422201238X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422201238X

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