Computational design and engineering of an Escherichia coli strain producing the nonstandard amino acid para-aminophenylalanine

Summary: Introducing heterologous pathways into host cells constitutes a promising strategy for synthesizing nonstandard amino acids (nsAAs) to enable the production of proteins with expanded chemistries. However, this strategy has proven challenging, as the expression of heterologous pathways can d...

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Bibliographic Details
Main Authors: Ali R. Zomorrodi, Colin Hemez, Pol Arranz-Gibert, Terrence Wu, Farren J. Isaacs, Daniel Segrè
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222008343