Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application

Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application

Triggered therapeutics are of interest but currently suffer from limited penetration depth of light sources. Here, the authors report on the development of a system, called radioswitch, that uses ionising irradiation to switch an azobenzene modified drug to an active form for deep tissue triggered t...

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Bibliographic Details
Main Authors: Alban Guesdon-Vennerie, Patrick Couvreur, Fatoumia Ali, Frédéric Pouzoulet, Christophe Roulin, Immaculada Martínez-Rovira, Guillaume Bernadat, François-Xavier Legrand, Claudie Bourgaux, Cyril Lucien Mazars, Sergio Marco, Sylvain Trépout, Simona Mura, Sébastien Mériaux, Guillaume Bort
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30917-0

Internet

https://doi.org/10.1038/s41467-022-30917-0

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