Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and therefore activates mTOR signaling and induces epigenetic modifications. SLC7A11 transports cystine and increases the cellular le...

Full description

Bibliographic Details
Main Authors: Marilyn Mathew, Sathish Sivaprakasam, Gunadharini Dharmalingam-Nandagopal, Souad R. Sennoune, Nhi T. Nguyen, Valeria Jaramillo-Martinez, Yangzom D. Bhutia, Vadivel Ganapathy
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Antioxidants
Subjects:
SLC38A5
SLC7A11
TNBC cells
seleno-methionine
glutathione
glutathione peroxidase
Online Access:https://www.mdpi.com/2076-3921/13/3/291

Internet

https://www.mdpi.com/2076-3921/13/3/291

Similar Items