Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells.

Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells.

The role of sonic hedgehog (SHH) in epithelial mesenchymal transition (EMT) of pancreatic cancer (PC) is known, however, its mechanism is unclear. Because SHH promotes tumor development predominantly through Gli1, we sought to understand its mechanism by identifying Gli1 targets in pancreatic cancer...

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Bibliographic Details
Main Authors: Xuanfu Xu, Yingqun Zhou, Chuangao Xie, Shu-mei Wei, Huizhong Gan, Shengli He, Fan Wang, Ling Xu, Jie Lu, Weiqi Dai, Lei He, Ping Chen, Xingpeng Wang, Chuanyong Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3416762?pdf=render

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http://europepmc.org/articles/PMC3416762?pdf=render

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