HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

Background: Quiescin sulfhydryl oxidase 1 (QSOX1), which oxidizes sulfhydryl groups to form disulfide bonds in proteins, is found to be over-expressed in various pancreatic cancer cell lines and patients. QSOX1 promotes invasion of pancreatic cancer cells by activating MMP-2 and MMP-9. However, its...

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Bibliographic Details
Main Authors: Chen-Ye Shi, Yue Fan, Bin Liu, Wen-Hui Lou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hypoxia
HIF-1
QSOX1
Matrix Metalloproteinase
Pancreatic Cancer Cell
Online Access:http://www.karger.com/Article/FullText/354460

Internet

http://www.karger.com/Article/FullText/354460

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