Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma

Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma

Oncogenesis of Ewing sarcoma (EwS), the second most common malignant bone tumor of childhood and adolescence, is dependent on the expression of chimeric EWSR1‐ETS fusion oncogenes, most often EWSR1‐FLI1 (E/F). E/F expression leads to dysregulation of focal adhesions (FAs) enhancing the migratory cap...

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Bibliographic Details
Main Authors: Konrad Steinestel, Marcel Trautmann, Esther‐Pia Jansen, Uta Dirksen, Jan Rehkämper, Jan‐Henrik Mikesch, Julia S. Gerke, Martin F. Orth, Giuseppina Sannino, Maria‐Francisca Arteaga, Claudia Rossig, Eva Wardelmann, Thomas G. P. Grünewald, Wolfgang Hartmann
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Molecular Oncology
Subjects:
cytoskeleton
Ewing sarcoma
focal adhesion kinase
metastasis
migration
Online Access:https://doi.org/10.1002/1878-0261.12610

Internet

https://doi.org/10.1002/1878-0261.12610

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