USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit

USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit

Establishment of translational competence represents a decisive cytoplasmic step in the biogenesis of 40S ribosomal subunits. This involves final 18S rRNA processing and release of residual biogenesis factors, including the protein kinase RIOK1. To identify novel proteins promoting the final maturat...

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Bibliographic Details
Main Authors: Christian Montellese, Jasmin van den Heuvel, Caroline Ashiono, Kerstin Dörner, André Melnik, Stefanie Jonas, Ivo Zemp, Paola Picotti, Ludovic C Gillet, Ulrike Kutay
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
ribosome biogenesis
translation
deubiquitinase
USP16
quality control
Online Access:https://elifesciences.org/articles/54435

Internet

https://elifesciences.org/articles/54435

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