SKF38393 prevents high glucose (HG)-induced endothelial dysfunction by inhibiting the effects of HG on cystathionine γ-lyase/hydrogen sulfide activity and via a RhoA/ROCK1 pathway

SKF38393 prevents high glucose (HG)-induced endothelial dysfunction by inhibiting the effects of HG on cystathionine γ-lyase/hydrogen sulfide activity and via a RhoA/ROCK1 pathway

Background: Endothelial dysfunction plays a crucial role in diabetic vascular complications. A decrease in hydrogen sulfide (H2S) levels is increasingly becoming a vital factor contributing to high glucose (HG)-induced endothelial dysfunction. Dopamine D1-like receptors (DR1) activation has importan...

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Bibliographic Details
Main Authors: Gui-Quan Chang, Shu-Zhi Bai, Feng-Qi Sun, Ren Wu, Can Wei, Xin Wen, Yu-Xin Xi, Jing-Hui Hao, Altaany Zaid, Hong-Zhu Li
Format: Article
Language:English
Published: IMR Press 2022-02-01
Series:Frontiers in Bioscience-Landmark
Subjects:
dopamine d1-like receptors
endothelial cells
hydrogen sulfide
high glucose
rhoa/rock1 pathway
Online Access:https://www.imrpress.com/journal/FBL/27/2/10.31083/j.fbl2702049

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https://www.imrpress.com/journal/FBL/27/2/10.31083/j.fbl2702049

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