The Complexity of Targeting PI3K-Akt-mTOR Signalling in Human Acute Myeloid Leukaemia: The Importance of Leukemic Cell Heterogeneity, Neighbouring Mesenchymal Stem Cells and Immunocompetent Cells

The Complexity of Targeting PI3K-Akt-mTOR Signalling in Human Acute Myeloid Leukaemia: The Importance of Leukemic Cell Heterogeneity, Neighbouring Mesenchymal Stem Cells and Immunocompetent Cells

Therapeutic targeting of PI3K-Akt-mTOR is considered a possible strategy in human acute myeloid leukaemia (AML); the most important rationale being the proapoptotic and antiproliferative effects of direct PI3K/mTOR inhibition observed in experimental studies of human AML cells. However, AML is a het...

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Bibliographic Details
Main Authors: Annette K. Brenner, Tor Henrik Andersson Tvedt, Øystein Bruserud
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
acute myeloid leukaemia
mesenchymal stem cells
therapy
stem cell niche
PI3K-Akt-mTOR
monocytes
membrane molecules
cytokine release
Online Access:http://www.mdpi.com/1420-3049/21/11/1512

Internet

http://www.mdpi.com/1420-3049/21/11/1512

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