Toward in vivo proof of binding of 18F-labeled inhibitor [18F]TRACK to peripheral tropomyosin receptor kinases

Toward in vivo proof of binding of 18F-labeled inhibitor [18F]TRACK to peripheral tropomyosin receptor kinases

Abstract Background Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a driver in multiple tumor types has increased interest in their role in human cancers...

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Bibliographic Details
Main Authors: Melinda Wuest, Justin J. Bailey, Jennifer Dufour, Darryl Glubrecht, Vanessa Omana, Tom H. Johnston, Jonathan M. Brotchie, Ralf Schirrmacher
Format: Article
Language:English
Published: SpringerOpen 2022-07-01
Series:EJNMMI Research
Subjects:
TrkA
TrkB
PET
Molecular imaging
Radiotracer
[18F]TRACK
Online Access:https://doi.org/10.1186/s13550-022-00915-w

Internet

https://doi.org/10.1186/s13550-022-00915-w

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