Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart

Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart

Excessive cardiac fibrosis, characterized by increased collagen-rich extracellular matrix (ECM) deposition, is a major predisposing factor for mechanical and electrical dysfunction in heart failure (HF). The human ventricular fibroblast (hVF) remodeling mechanisms that cause excessive collagen depos...

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Bibliographic Details
Main Authors: Gracious R. Ross, Tanvir Bajwa, Stacie Edwards, Larisa Emelyanova, Farhan Rizvi, Ekhson L. Holmuhamedov, Paul Werner, Francis X. Downey, A. Jamil Tajik, Arshad Jahangir
Format: Article
Language:English
Published: The Company of Biologists 2017-03-01
Series:Biology Open
Subjects:
Calcium
Cardiac fibrosis
Store-operated Ca2+ entry
Heart failure
Online Access:http://bio.biologists.org/content/6/3/326

Internet

http://bio.biologists.org/content/6/3/326

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