MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation

MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation

Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A‐type lamins. Progerin, a truncated and toxic prelamin A issued from aberrant splicing, accumulates in HGPS cells' nuclei and is a hallma...

Full description

Bibliographic Details
Main Authors: Karim Harhouri, Claire Navarro, Danielle Depetris, Marie‐Geneviève Mattei, Xavier Nissan, Pierre Cau, Annachiara De Sandre‐Giovannoli, Nicolas Lévy
Format: Article
Language:English
Published: Springer Nature 2017-09-01
Series:EMBO Molecular Medicine
Subjects:
autophagy
MG132
PML‐NBs
progerin
splicing
Online Access:https://doi.org/10.15252/emmm.201607315

Internet

https://doi.org/10.15252/emmm.201607315

Similar Items