Defining the Cynomolgus Macaque (<i>Macaca fascicularis</i>) Animal Model for Aerosolized Venezuelan Equine Encephalitis: Importance of Challenge Dose and Viral Subtype

Defining the Cynomolgus Macaque (<i>Macaca fascicularis</i>) Animal Model for Aerosolized Venezuelan Equine Encephalitis: Importance of Challenge Dose and Viral Subtype

Venezuelan equine encephalitis virus (VEEV) outbreaks occur sporadically. Additionally, VEEV has a history of development as a biothreat agent. Yet, no FDA-approved vaccine or therapeutic exists for VEEV disease. The sporadic outbreaks present a challenge for testing medical countermeasures (MCMs) i...

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Bibliographic Details
Main Authors: Crystal W. Burke, Christina L. Gardner, Aimee I. Goodson, Ashley E. Piper, Rebecca A. Erwin-Cohen, Charles E. White, Pamela J. Glass
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Viruses
Subjects:
Venezuelan equine encephalitis virus
cynomolgus macaque
animal model
aerosol exposure
medical countermeasures
nonhuman primates
Online Access:https://www.mdpi.com/1999-4915/15/12/2351

Internet

https://www.mdpi.com/1999-4915/15/12/2351

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