Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). Few studies have explored dendritic morphology phenotypes in mouse models of RTT and none have determined whether these phenotypes in affected females...

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Bibliographic Details
Main Authors: Nadia P. Belichenko, Pavel V. Belichenko, William C. Mobley
Format: Article
Language:English
Published: Elsevier 2009-04-01
Series:Neurobiology of Disease
Subjects:
Rett syndrome
MeCP2
Mouse models
Brain
Motor cortex
Spines
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108003136

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http://www.sciencedirect.com/science/article/pii/S0969996108003136

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