Reference standards for accurate validation and optimization of assays that determine integrated lentiviral vector copy number in transduced cells

Reference standards for accurate validation and optimization of assays that determine integrated lentiviral vector copy number in transduced cells

Abstract Lentiviral vectors (LV) have emerged as a robust technology for therapeutic gene delivery into human cells as advanced medicinal products. As these products are increasingly commercialized, there are concomitant demands for their characterization to ensure safety, efficacy and consistency....

Full description

Bibliographic Details
Main Authors: Barbara S. Paugh, Lajos Baranyi, Andre Roy, Hua-Jun He, Lindsay Harris, Kenneth D. Cole, Moria Artlip, Caroline Raimund, Patricia S. Langan, Srikanta Jana, Rimas J. Orentas, Sheng Lin-Gibson, Winfried Krueger, Boro Dropulić
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79698-w

Internet

https://doi.org/10.1038/s41598-020-79698-w

Similar Items