Hyperammonaemia induces mitochondrial dysfunction and neuronal cell death

Hyperammonaemia induces mitochondrial dysfunction and neuronal cell death

Background & Aims: In cirrhosis, astrocytic swelling is believed to be the principal mechanism of ammonia neurotoxicity leading to hepatic encephalopathy (HE). The role of neuronal dysfunction in HE is not clear. We aimed to explore the impact of hyperammonaemia on mitochondrial function in...

Full description

Bibliographic Details
Main Authors: Plamena R. Angelova, Annarein J.C. Kerbert, Abeba Habtesion, Andrew Hall, Andrey Y. Abramov, Rajiv Jalan
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:JHEP Reports
Subjects:
Liver cirrhosis
Hepatic encephalopathy
Ammonia
Mitochondrial function
Cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555922000829

Internet

http://www.sciencedirect.com/science/article/pii/S2589555922000829

Similar Items