Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

PEP06 is a novel endostatin-Arg-Gly-Asp-Arg-Gly-Asp (RGDRGD) 30-amino-acid polypeptide featuring a terminally fused RGDRGD hexapeptide at the N terminus. The active endostatin fragment of PEP06 directly targets tumor cells and exerts an antitumoral effect. However, little is known about the kinetics...

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Bibliographic Details
Main Authors: Liyun Niu, Huiyu Zhou, Yueru Lian, Ya Gao, Yulu Liu, Ruolan Gu, Zhuona Wu, Xiaoxia Zhu, Hui Gan, Zhiyun Meng, Guifang Dou
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Pharmaceutical Analysis
Subjects:
PEP06
HRMS
Metabolic stability
Metabolites identification
Online Access:http://www.sciencedirect.com/science/article/pii/S209517792200020X

Internet

http://www.sciencedirect.com/science/article/pii/S209517792200020X

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